|
|
Î÷ºçÍø
Î÷ºçÍø¡¡¡¡Ð¹ÚÒßÇéËÁŰ£¬´óÁ¿¸ßÁäÀÏÈËÒòÒßÀëÊÀÈÇÈ˾¾ÐÄ¡£ÔÚ¹Ù·½·¢²¼µÄͨ±¨ÖУ¬ÅÁ½ðɲ¡¡¢°¢¶û´Äº£Ä¬Ö¢³£×÷ΪȥÊÀÀÏÈ˵Ĺ²»¼¼²²¡³öÏÖ¡£NMNhttps://www.nmn.cn/µÄÏà¹ØÎÊÌâ¿ÉÒÔµ½ÍøÕ¾Á˽âÏ£¬ÎÒÃÇÊÇÒµÄÚÁìÓòרҵµÄƽ̨£¬ÄúÈç¹ûÓÐÐèÒª¿ÉÒÔ×Éѯ£¬ÏàÐÅ¿ÉÒÔ°ïµ½Äú£¬ÖµµÃÄúµÄÐÅÀµ£¡ Î÷ºçÍø
Î÷ºçÍø Î÷ºçÍø
Î÷ºçÍø Î÷ºçÍø
Î÷ºçÍø¡¡¡¡Ëæ×ÅÈË¿ÚÀÏÁ仯¼Ó¾ç£¬Ë¥ÀÏÏà¹Ø¼²²¡ÈÕÒæÊܵ½¹Ø×¢£¬ÆäÖÐÉñ¾ÍËÐÐÐÔ¼²²¡¸üÊDZ¸ÊÜÖØÊӵĽ¹µã¡£°¢¶û´Äº£Ä¬Ö¢£¨AD£©¡¢ÅÁ½ðɲ¡£¨PD£©¡¢¼¡ÈâήËõÐÔ²àË÷Ó²»¯Ö¢£¨ALS£©¡¢¶à·¢ÐÔÓ²»¯Ö¢£¨MS£©µÈ¶¼ÊôÓÚ³£¼ûµÄÉñ¾ÍËÐÐÐÔ¼²²¡¡£ Î÷ºçÍø
Î÷ºçÍø Î÷ºçÍø
Î÷ºçÍø¡¡¡¡ÕâÀ༲²¡ÊÇÓÉÓÚ´óÄԺͼ¹ËèµÄÉñ¾ÔªÖð½¥ÍË»¯ËùÖ£¬²¡ÇéËæ×ÅÄêÁäÔö³¤²»¶Ï¶ñ»¯£¬×îÖÕµ¼Ö»¼ÕßʧÄÜ¡¢ËÀÍö¡£¸ù¾ÝÊÀ½çÎÀÉú×éÖ¯£¨WHO£©Ô¤²â£ºµ½2040Ä꣬Éñ¾ÍËÐÐÐÔ¼²²¡½«È¡´ú°©Ö¢£¬³ÉΪÈËÀàµÚ¶þ´óÖÂËÀ¼²²¡[1]¡£ Î÷ºçÍø
Î÷ºçÍø Î÷ºçÍø
Î÷ºçÍø¡¡¡¡Í¼×¢£ºÈ¥ÄêÈȲ¥µÄÒ»µµ¹Ø×¢»¼ÓÐÉñ¾ÍËÐÐÐÔ¼²²¡ÀÏÈ˵Ĺ«Òæ½ÚÄ¿¡¶Íü²»Á˲ÍÌü¡· Î÷ºçÍø
Î÷ºçÍø Î÷ºçÍø
Î÷ºçÍø¡¡¡¡»¼²¡ÈËÊý¹ã¡¢¼²²¡¸ºµ£´ó£¬ÖÂʹÈËÃDz»¶ÏÍÆ¶¯Éñ¾ÍËÐÐÐÔÖÎÁÆÒ©Î↑·¢½ø³Ì¡£µ«¹¥¿Ë´ËÀ༲²¡Ò»Ö±¶¼ÊÇÒ©Î↑·¢ÁìÓò¡°ÄѿеÄÓ²¹ÇÍ·¡±¡£Ä¿Ç°µÄÒ©Îï½öÄܼõÇᲿ·ÖÖ¢×´£¬È´Ã»ÓÐÒ»ÖÖÒ©ÎïÄܹ»ÓÐЧ×èÖ¹Éñ¾Ï¸°ûÍËÐкÍËÀÍö¡£ Î÷ºçÍø
Î÷ºçÍø Î÷ºçÍø
Î÷ºçÍø¡¡¡¡ÏÈǰÑо¿·¢ÏÖ£¬·¢ÉúÉñ¾ÍËÐеÄÉñ¾Ï¸°ûÖÐNAD+ˮƽÃ÷ÏÔ½µµÍ£¬Òý·¢ÖáÍ»ÍË»¯¡£¶øÁ½ÖÖÌáÉýNAD+µÄ²ßÂÔ¿ÉÒÔ·ÀÖ¹ÖáÍ»ÍË»¯ÒÔ±£»¤Éñ¾Ï¸°û£ºÒ»ÊÇ£¬Í¨¹ýNAD+ǰÌå²¹³ä¼ÁÖ±½Ó»Ö¸´NAD+ˮƽ£»¶þÊÇ£¬¹ý±í´ïÓëNAD+ºÏ³ÉÏà¹ØµÄÁ½ÖÖøNAMPTºÍNMNATÒÔÔöÇ¿NAD+ºÏ³ÉËÙÂÊ[2]¡£ Î÷ºçÍø
Î÷ºçÍø Î÷ºçÍø
Î÷ºçÍø¡¡¡¡NAD+µÄǰÌå²¹³ä¼ÁNMNºÍNR×÷Ϊ¿¹Ë¥ÀÏʳƷ²¹³ä¼ÁÔÚÊг¡ÉÏÈÈÏú£¬ÔÚ¶¯ÎïÄ£ÐÍÖÐÕ¹ÏÖ³ö¶Ô¿¹°¢¶û´Äº£Ä¬Ö¢¡¢ÅÁ½ðɲ¡µÈÉñ¾ÍËÐÐÐÔ¼²²¡µÄDZÁ¦£¬Ïà¹ØÁÙ´²ÊÔÑéÒ²ÔÚ½ôÂàÃܹĵسﱸÖÐ[2]¡£ Î÷ºçÍø
Î÷ºçÍø Î÷ºçÍø
Î÷ºçÍø¡¡¡¡¶øÀ´×ÔÇ廪´óѧҩѧԺµÄÍõ¸êÁÖºÍÌÆÒ¶·åÍŶӶ¢ÉÏÁËÈ˼£º±ÖÁµÄÁíÒ»ÌõµÀ·¡ª¡ª¿ª·¢NAD+ÉúÎïºÏ³ÉµÄÏÞËÙø£¬ÑÌõ£°·Á×ËáºËÌÇ»ù×ªÒÆÃ¸£¨NAMPT£©µÄÐÂÐÍС·Ö×Ó¼¤»î¼Á£¨NATs£©£¬´Ù½øNAD+×ÔÉíºÏ³É¡£ Î÷ºçÍø
Î÷ºçÍø Î÷ºçÍø
Î÷ºçÍø¡¡¡¡ÈÕǰ£¬ÕâÏ×÷È¡µÃÁ˾޴ó½øÕ¹£¬³É¹û·¢±íÔÚ¡¶×ÔÈ»¡·ÔÓÖ¾£¨Nature£©×Ó¿¯Cell ResearchÉÏ£¬Òý·¢´ó¼Ò¹Ø×¢[3]¡£ Î÷ºçÍø
Î÷ºçÍø Î÷ºçÍø
Î÷ºçÍø¡¡¡¡/// Î÷ºçÍø
Î÷ºçÍø Î÷ºçÍø
Î÷ºçÍø¡¡¡¡Ï¸°ûÄÚµÄNAMPTÊÇNAD+²¹¾ÈºÏ³É;¾¶ÉϵĹؼüø¡£NAD+ÓëNADÏûºÄø£¨Sirtuins¡¢PARPsµÈ£©×÷Óúó£¬×ª»¯ÎªÑÌõ£°·£¨NAM£©¡£NAMPT±ã¿ÉÒÔ°ÑÑÌõ£°·Ê°¶Þ»ØÀ´£¬¡°±ä·ÏΪ±¦¡±ºÏ³ÉNMN£¬NMNÔÙ¾NMNATת»¯ÎªÈËÈ˶¼°®µÄNAD+ [4]¡£ Î÷ºçÍø
Î÷ºçÍø Î÷ºçÍø
Î÷ºçÍø¡¡¡¡Ò²¾ÍÊÇ˵£¬ÔÚNAMPT¸øÁ¦¼Ó³ÖÏ£¬ÓпÉÄÜʵÏÖNAD+µÄ¡°×ÔÑ»·¡±¡£½áºÏÉÏË¥ÀÏÊÇNAD+ÏûºÄ¹ý¶àµÄ½á¹ûÕâÒ»±³¾°[5]£¬¼¤»îNAMPTÒâζ×ŶԿ¹Ë¥ÀÏ£¬ºÁÎÞÒÉÎÊ£¬Ò²ÄܶÔÉñ¾ÍËÐÐÐÔ¼²²¡ÏÔЧ¡£ Î÷ºçÍø
Î÷ºçÍø Î÷ºçÍø
Î÷ºçÍø¡¡¡¡NAMPT¾ÍÕâÑù³ÉΪÁËÇ廪ÍŶӵÄÄ¿±ê¡£¿ÉÊÇ£¬Ã¸¼¤»î¼ÁµÄ·¢ÏÖ¼«¾ßÌôÕ½ÐÔ¡£Ïà½ÏøÒÖÖÆ¼Á£¬Ä¿Ç°Äܹ»³É¹¦Ó¦ÓõÄø¼¤»î¼ÁÁÈÁÈÎÞ¼¸£¨´Ë´¦Ïëµ½Á˱»´óÎÀ¡¤ÐÁ¿ËÀ³µÄ°×޼«´¼£¬Ò»ÖÖSIRT1¼¤»î¼Á£¬Æµ½¡°¿Ú³ö¶ñÑÔ¡±µÄÒ©ÆóGSK£©¡£ Î÷ºçÍø
Î÷ºçÍø Î÷ºçÍø
Î÷ºçÍø¡¡¡¡/// Î÷ºçÍø
Î÷ºçÍø Î÷ºçÍø
Î÷ºçÍø¡¡¡¡Ê×ÏÈ£¬Ç廪ÍŶӴӺÆÈçÑ̺£µÄ50000¶àÖÖ»¯Ñ§ÎïÖÊÖУ¬É¸Ñ¡³öÁËΨһÄܹ»Ç¿Á¦¼¤»îNAMPTµÄ·Ö×Ó£¬½«ÆäÊÓ×÷NAT£¨NAMPTǿЧ¼¤»î¼Á£©ÒÔ±¸Ñо¿¡£ Î÷ºçÍø
Î÷ºçÍø Î÷ºçÍø
Î÷ºçÍø¡¡¡¡Í¨¹ýXÉäÏßÑÜÉä·ÖÎö¼¼Êõ£¬Ñо¿ÈËÔ±½âÎöÁËNAMPTÓëNATµÄ¾§Ìå½á¹¹£¬´ÓÔ×Óˮƽ¹Û²ìµ½NAT×êÈëNAMPT´ß»¯¿Ú´üÄÚ²¿£¬´Ù½øÑÌõ£°·ºÍPRPP£¨àÑßʺËÜÕËáµÄǰÌ壩ËõºÏÐγÉNMN£¨ÑÌõ£°·µ¥ºËÜÕËᣩ£¬ÌáÉýNAMPTµÄ´ß»¯Ð§ÂÊ¡£ Î÷ºçÍø
Î÷ºçÍø Î÷ºçÍø
Î÷ºçÍø¡¡¡¡È»ºó£¬ÎªÁ˽øÒ»²½ÌáÉýNATµÄЧÁ¦ºÍÒ©ÀíÌØÐÔ£¬Ñо¿ÈËÔ±¶ÔNAT½øÐÐÁËϵͳµÄ·Ö×ӽṹÐÞÊκÍÓÅ»¯¡£´Ó5ÂÖÓÅ»¯ÖкϳɵÄ81ÖÖÑÜÉúÎïÖУ¬ÓÖÑ¡³öÁËÒ»ÖÖ×î»îÔ¾µÄÑÜÉúÎïNAT-5r£¨ÔÚNAT×ó²àA»·ÉÏÌí¼ÓÒ»¸öÇè»ù£©¡£ Î÷ºçÍø
Î÷ºçÍø Î÷ºçÍø
Î÷ºçÍø¡¡¡¡¾ßÌåµÄÓÅ»¯ÐÞÊιý³Ì¼°¹¹Ð§¹ØÏµÑо¿£¬×÷ΪÁíһƪÂÛÎÄ·¢±íÔÚÁË¡¶Å·ÖÞÒ©Îﻯѧ¡·ÔÓÖ¾[6]¡£ Î÷ºçÍø
Î÷ºçÍø Î÷ºçÍø
Î÷ºçÍø¡¡¡¡×îºó£¬Ñо¿ÈËÔ±ÓÃNAMPTµÄÇ¿Á¦ÒÖÖÆ¼ÁFK866£¬¶ÔNAT-5r½øÐÐÁË¡°×îÖÕÊÔÁ¶¡±¡£ÔÚϸ°ûÅàÑø»ùÖÐÌí¼ÓFK866¿Éʹϸ°ûÄÚNAD+ѸËÙÏûºÄ£¬µ¼ÖÂϸ°ûËÀÍö£¬¶øÊ©ÓÃNAT-5r¿ÉÒÔ±£»¤Ï¸°ûÃâÊÜFK866µÄ¶¾º¦¡£ Î÷ºçÍø
Î÷ºçÍø Î÷ºçÍø
Î÷ºçÍø¡¡¡¡NAT-5rÍê³ÉËùÓС°³ö³§¼ìÑ顱£¬×÷ΪNAMPT¼¤»î¼Á£¬¼´½«Ó½ÓȫеÄÌôÕ½¡£ Î÷ºçÍø
Î÷ºçÍø Î÷ºçÍø
Î÷ºçÍø¡¡¡¡/// Î÷ºçÍø
Î÷ºçÍø Î÷ºçÍø
Î÷ºçÍø¡¡¡¡ÔÚ´ó¼ÁÁ¿¸øÒ©È·¶¨NAT-5r¶Ôϸ°û²»´æÔÚ¶¾ÐÔÖ®ºó£¬Ñо¿ÈËÔ±¿ªÊ¼ÀûÓÃ̼14±ê¼ÇµÄÑÌõ£°·£¬À´¼ìÑéNAT-5rÄÜ·ñÌáÉýϸ°ûÄÚNAD+ºÏ³ÉËÙÂÊ¡£ Î÷ºçÍø
Î÷ºçÍø Î÷ºçÍø
Î÷ºçÍø¡¡¡¡½á¹û·¢ÏÖ£¬Ê¹ÓÃ3¦ÌMŨ¶ÈµÄNAT-5rÅàÑøÏ¸°û4Сʱºó£¬Ï¸°ûÄÚNAD+ˮƽ±ã³öÏÖÁËÏÔÖøÉý¸ß£¬Æä³Ì¶È·Ö±ðÓë300¦ÌMµÄNMNºÍ1mMµÄNRÏ൱¡£ Î÷ºçÍø
Î÷ºçÍø Î÷ºçÍø
Î÷ºçÍø¡¡¡¡ÕâÒâζ×Å£¬NAT-5rÌáÉýNAD+µÄËÙÂÊ£¬ÊÇNMNµÄ100±¶£¬NRµÄ333±¶¡£ Î÷ºçÍø
Î÷ºçÍø Î÷ºçÍø
Î÷ºçÍø¡¡¡¡Éñ¾¸Éϸ°û£¨NSC£©ÊÇÉñ¾ÔªºÍÉñ¾½ºÖÊϸ°ûµÄÖÕÉúÀ´Ô´¡£ÔÚȱ·¦Éú³¤Òò×ÓµÄÓ¦¼¤Ìõ¼þÏ£¬Éñ¾¸Éϸ°ûÔöֳͣÖÍ£¬´ËʱÍùÅàÑø»ùÖÐÌí¼ÓNAT-5r£¬·¢ÏÖËüÖØÐÂÆô¶¯ÁËÉñ¾¸Éϸ°ûµÄÔöÖ³¡£ Î÷ºçÍø
Î÷ºçÍø Î÷ºçÍø
Î÷ºçÍø¡¡¡¡¶øÔö´óÌí¼ÓµÄNAT-5rµÄŨ¶È´ï3¦ÌM£¬·¢ÏÖÉñ¾¸Éϸ°ûÔöÖ³Êܵ½ÒÖÖÆ£¬¿ªÊ¼×ªÎªÏòÉñ¾Ôª»òÉñ¾½ºÖÊϸ°ûµÄ·Ö»¯¡£ÕâÖÖ¡°¹³×ÓЧӦ¡±Í¬NMNÏàËÆ£¬µ±NMNŨ¶È³¬¹ý300¦ÌMʱ£¬Ò²»á·¢ÉúÔöÖ³Ïò·Ö»¯µÄת±ä£¬Õâ¿ÉÄÜÓëNAMPT¹ý¶È¼¤»îÓйء£ Î÷ºçÍø
Î÷ºçÍø Î÷ºçÍø
Î÷ºçÍø¡¡¡¡/// Î÷ºçÍø
Î÷ºçÍø Î÷ºçÍø
Î÷ºçÍø¡¡¡¡Ï¸°ûʵÑé¸æÒ»¶ÎÂ䣬Ñо¿ÈËÔ±¿ªÊ¼×ÅÊÖ¶¯ÎïʵÑé¡£ Î÷ºçÍø
Î÷ºçÍø Î÷ºçÍø
Î÷ºçÍø¡¡¡¡Ñо¿ÈËÔ±ÀûÓû¯ÁÆÒ©Îï×Ïɼ´¼ÓÕµ¼Ð¡ÊóÉñ¾ËðÉËÒÔÖÆÔ춯ÎïÄ£ÐÍ£¬»¯ÁÆÒ©Îï¿É´óÁ¿ÏûºÄNAD+£¬ËðÉËÖÜΧÉñ¾µÄÖáÍ»£¬Æä²¡Àí±íÏÖÀàËÆÓÚÉñ¾ÍËÐÐÐԱ䡣 Î÷ºçÍø
Î÷ºçÍø Î÷ºçÍø
Î÷ºçÍø¡¡¡¡ÔÚ¿ªÊ¼×¢Éä×Ïɼ´¼£¨PTX£©µÄǰ1ÖÜ£¬ÏȸøÐ¡Êó×¢ÉäNATºÍNAT-5r½øÐб£»¤¡£ Î÷ºçÍø
Î÷ºçÍø Î÷ºçÍø
Î÷ºçÍø¡¡¡¡²»³öÒâÁÏ£¬Ê©ÓÃNATºÍNAT-5rºó£¬Éñ¾Ï¸°ûÄÚNADˮƽÌáÉý£¬ÉõÖÁÂÔ¸ßÓÚδעÉä×Ïɼ´¼µÄ¿Õ°×¶ÔÕÕ×é¡£ Î÷ºçÍø
Î÷ºçÍø Î÷ºçÍø
Î÷ºçÍø¡¡¡¡Í¨¹ý¶ÔСÊó×ø¹ÇÉñ¾½øÐÐ×é֯ѧ·ÖÎö±íÃ÷£¬3mg/kgºÍ30mg/kgµÄNAT-5r¾ùÈÃСÊóÃâÓÚ»¯ÁÆÒ©Ôì³ÉµÄÉñ¾ËðÉË£¬ÆäЧÓÃÓë30mg/kgµÄNATÏ൱¡£ Î÷ºçÍø
Î÷ºçÍø Î÷ºçÍø
Î÷ºçÍø¡¡¡¡/// Î÷ºçÍø
Î÷ºçÍø Î÷ºçÍø
Î÷ºçÍø¡¡¡¡Ê¹ÓÃС·Ö×ÓNAMPT¼¤»î¼Á£¬¿ÉʹСÊóÉñ¾Ï¸°ûµÃµ½±£»¤£¬²¢ÇÒ¹ý³ÌÖÐûÓз¢ÏÖÈκζ¾¸±×÷Óá£ÕâΪÉñ¾ÍËÐÐÐÔ¼²²¡µÄÒ©ÎïÑз¢Ö¸Ã÷ÁË·½Ïò¡£ Î÷ºçÍø
Î÷ºçÍø Î÷ºçÍø
Î÷ºçÍø¡¡¡¡´ËÍ⣬Ñо¿ÈËÔ±Ö¸³ö£¬Ïà½ÏÓÚNMNºÍNRµÈÓªÑø²¹³ä¼Á£¬NAMPT¼¤»î¼Á¾ßÓÐÒÔÏÂ4´óÓÅÊÆ£º Î÷ºçÍø
Î÷ºçÍø Î÷ºçÍø
Î÷ºçÍø¡¡¡¡NAT-5rÌáÉýNAD+ˮƽ£¬±ÈNMNºÍNR¸ü¸ßЧ£¨100±¶/333±¶£© Î÷ºçÍø
Î÷ºçÍø Î÷ºçÍø
Î÷ºçÍø¡¡¡¡NAT-5rÕâÒ»ÀàС·Ö×Ó¼¤»î¼ÁÏà½ÏNMNºÍNRµÈǰÌå¾ßÓиüºÃµÄÉúÎïÀûÓöȣ¬Äܹ»¸ü¿ìµÝË͵½×éÖ¯²¢ÀûÓà Î÷ºçÍø
Î÷ºçÍø Î÷ºçÍø
Î÷ºçÍø¡¡¡¡NAMPTС·Ö×Ó¼¤»î¼ÁºÏ³ÉÈÝÒ×£¬³É±¾ºÜµÍ£¬²»»áºÍNMN¡¢NRÒ»Ñù³ÉΪ¸»È˶ÀÏíµÄ¡°²»ÀÏÒ©¡± Î÷ºçÍø
Î÷ºçÍø Î÷ºçÍø
Î÷ºçÍø¡¡¡¡NAMPT¼¤»î¼ÁµÄ×÷ÓÃÔÚÏÞËÙ²½ÖèÉÏÊܵ½µ÷½Ú£¬Äܹ»¸üÁé»îµØÂú×㲻ͬÉúÀí״̬ÏÂϸ°ûµÄÐèÒª Î÷ºçÍø
Î÷ºçÍø Î÷ºçÍø
Î÷ºçÍø¡¡¡¡´ËÏîÑо¿ÓÉÇ廪´óѧҩѧԺµÄÍõ¸êÁÖ½ÌÊÚºÍÌÆÒ¶·å½ÌÊÚ¹²Í¬Íê³É¡£Íõ½ÌÊÚ³¤ÆÚרעÓÚÉñ¾±£»¤Ò©Î↑·¢£¬µÚÒ»ÖÖÄܹ»¼¤»îNAMPTµÄС·Ö×ÓP7C3Ò²ÊÇÓÉËý·¢ÏÖ£»ÌƽÌÊÚÔÚÓлúºÏ³É»¯Ñ§ºÍÒ©Óû¯Ñ§ÁìÓòÓÐןÜÉîµÄÔìÒ裬³É¹¦¿ª·¢ÁË´óÁ¿Ò©ÎïºÏ³Éз½·¨¡£Ë«½£ºÏèµ£¬¹²Í¬¡°ÍÚ¾ò¡±³öÁËȫеÄNAT£¬²¢¶ÔÆä½øÐÐÁËÀíÐÔµÄÓÅ»¯¸ÄÔ죬Ϊ¿ª·¢ÖÎÁÆÉñ¾ÍËÐÐÐÔ¼²²¡µÄÐÂÒ©µì¶¨Á˼áʵ»ù´¡¡£ Î÷ºçÍø
Î÷ºçÍø Î÷ºçÍø
Î÷ºçÍø¡¡¡¡¡ª¡ª TIMEPIE ¡ª¡ª Î÷ºçÍø
Î÷ºçÍø Î÷ºçÍø
Î÷ºçÍø¡¡¡¡×îÐÂÑо¿µÄNADºÏ³É¼¤»î¼ÁºóÐø»ò¿ÉÓëNMNÁ¬Óã¬Ïà¹ØÑо¿Ê±¹âÅɽ«¸ú½ø±¨µÀ¡£ Î÷ºçÍø
Î÷ºçÍø Î÷ºçÍø
Î÷ºçÍø¡¡¡¡¡¾NMN×îзþÓÃÖ¸ÄÏ¡¿£¬ÏÞÓÚÆª·ù²»ÔÚÎÄÖÐÕ¹¿ª¡£ Î÷ºçÍø
Î÷ºçÍø Î÷ºçÍø
Î÷ºçÍø¡¡¡¡Ò²»¶Ó¶ÁÕß¾ÍNMN·þÓá¢ÌôÑ¡µÄÒÉÎʺÍÎÒÃÇÆÀÂÛÇø»ò˽ÐŽøÐн»Á÷¡£ Î÷ºçÍø
Î÷ºçÍø Î÷ºçÍø
Î÷ºçÍø¡¡¡¡²Î¿¼ÎÄÏ× Î÷ºçÍø
Î÷ºçÍø Î÷ºçÍø
Î÷ºçÍø¡¡¡¡[1] Gammon, K. Neurodegenerative disease: Brain windfall. Nature. 2014; 515:299¨C300. Î÷ºçÍø
Î÷ºçÍø Î÷ºçÍø
Î÷ºçÍø¡¡¡¡[2] Covarrubias AJ, Perrone R, Grozio A, et al. NAD+ metabolism and its roles in cellular processes during ageing. Nat Rev Mol Cell Biol. 2021;22(2):119-141. Î÷ºçÍø
Î÷ºçÍø Î÷ºçÍø
Î÷ºçÍø¡¡¡¡[3] Yao H, Liu M, Wang L, et al. Discovery of small-molecule activators of nicotinamide phosphoribosyltransferase (NAMPT) and their preclinical neuroprotective activity. Cell Res. 2022 Apr 22. doi: 10.1038/s41422-022-00651-9. Î÷ºçÍø
Î÷ºçÍø Î÷ºçÍø
Î÷ºçÍø¡¡¡¡[4] Bogan KL, Brenner C. Nicotinic acid, nicotinamide, and nicotinamide riboside: a molecular evaluation of NAD+ precursor vitamins in human nutrition. Annu Rev Nutr. 2008;28:115-30. Î÷ºçÍø
Î÷ºçÍø Î÷ºçÍø
Î÷ºçÍø¡¡¡¡[5] Covarrubias AJ, Kale A, Perrone R, et al. Author Correction: Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages. Nat Metab. 2021;3(1):120-121. Î÷ºçÍø
Î÷ºçÍø Î÷ºçÍø
Î÷ºçÍø¡¡¡¡[6] Wang L, Liu M, Zu Y, et al. Optimization of NAMPT activators to achieve in vivo neuroprotective efficacy. Eur J Med Chem. 2022;236:114260. doi: 10.1016/j.ejmech.2022.114260. Î÷ºçÍø
Î÷ºçÍø Î÷ºçÍø
Î÷ºçÍø¡¡¡¡¾Ù±¨/·´À¡ |
|